When your adrenal glands become exhausted so will you. After all, your adrenal glands help you deal with stress. They are very vulnerable to fatigue given they are responsible for your fight-or-flight response. Generally the more stress you have in your life, the more vitamin C your adrenal glands will need to operate effectively.
Collagen is just not responsible for smooth, healthy skin and healthy connective tissue. Collagen also keeps the inside of the arteries and veins smooth. Healthy arteries and veins must remain flexible so they can stretch when the heart pumps blood to circulate throughout body.
People who consume high doses of vitamin C do not show the expected mental and physical signs of stress, which often manifests as, but not limited to, communicable disease. These are the people that despite the snifflers and sneezers that surround them, seem to repel viruses. When they do succumb, they overcome quickly and more efficiently then most of society. Vitamin C has been proven time and time again to be able to reduce physical stress, even the kind of stress intentionally inflicted from vigorous exercise! Now before you use this information as an excuse to avoid the gym, it is important to realize that your car cannot travel 50 miles if there is only 20 miles worth of gas...